BAY AREA PHARMACOKINETIC AND PHARMACODYNAMICS (BAPKPD) NETWORK
invites you to
A LUNCHEON SEMINAR
A Mechanistic Model of the Renin-Angiotensin System (RAS) in the Renal Circulation
Dr. Arthur Lo
MAY 3 (THURSDAY), 2012
11:30 AM-1:30 PM PDT
THERAVANCE
901 GATEWAY BLVD
SOUTH SAN FRANCISCO, CA 94080
ROOM 1004/5
11:30 am - 12:00 pm Sign in and lunch
12:00 pm - 1:30 pm Seminar and Q and A
Abstract:
With the increased number of therapies for hypertension focusing on the renin-angiotensin system (RAS), there is evidence that some therapies are more effective at preventing end organ damage. Although the role of angiotensin II (Ang II) is well known and the systemic concentrations well characterized, the dynamics of Ang II within the kidney itself are less well characterized. This talk will walk through the development of a mechanistic model of the RAS that was built to predict the effects of different types of therapies on the concentrations of Ang II. The focus will be on teasing out RAS dynamics in the renal circulation, a location that is difficult to directly assay local peptide concentrations. Alternative sources of data for calibration and validation will be discussed, as well as the research applications of the model.
About the Speaker:
Dr. Lo is a senior scientist in Drug Metabolism and Pharmacokinetics at Theravance, where he is tasked with bringing in modeling and simulation to develop insights and enhance the decision making process in drug development. Arthur was previously at Entelos, where he led and was involved in the development of many systems biology models, including a large scale model of blood pressure regulation and renal function in collaboration with Novartis. He has also worked with different pharmaceutical companies using models of human metabolism and cardiovascular disease in projects across pipeline of research and development. Arthur received his Ph.D. in Applied Mathematics and Biomedical Engineering from the University of Arizona.
Registration
Registration is now open.
Normal Registration: [after April 25, 2012] $20 per person
(Free for pre-approved full-time students, postdocs, and the unemployed; see below)
Note: There is no on-site registration but you may register online up until 10:00 AM on the day of the event.
To view event flyer click here
For questions about the event and for pre-approval of special registration fees, please contact Smita Kshirsagar at
smitakshirsagar@hotmail.com